Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria
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منابع مشابه
Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria
Methods Ascaridole was synthesized from alpha-terpinene and characterized by NMR and IR spectroscopy. The toxic effects of these compounds on macrophages from BALB/c mice and on the bioenergetics of submitochondrial particles from bovine heart (SMP) and rat liver mitochondria (RLM) were studied. Toxic radical intermediates arising from the endoperoxide ascaridole were characterized by ESR spect...
متن کاملAscaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle.
Infusions of Chenopodium ambrosioides (L.) have been used for centuries in the Americas as a popular remedy against intestinal worm infections. The essential oil of Chenopodium ambrosioides contains high levels of ascaridole, which is a potent anthelmintic, but which has also been responsible for human fatalities, leading to its disuse. Almost 90% of the nematocidal activity of Chenopodium ambr...
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Chenopodium ambrosioides is an important medicinal plant widely used in the traditional medicine all over the word. Its folk medicinal uses include its antidiabetic profile. A study was designed to determine its hypoglycemic effect. mice used in experiment were fed with high-fat diet for two weeks before induction of Diabetes mellitus by injection of streptozocine (STZ). Animals treated with cr...
متن کاملAscaridole and related peroxides from the genus Chenopodium.
AIM Detection of monoterpenoid ascaridole and other terpenoids in the genus Chenopodium from the East Mediterranean. METHOD Distribution of ascaridole in leaves of 13 species medicinal plant belonging to the genus Chenopodium was examined with the help of the GC MS method. RESULTS cis Ascaridole was found as a major peroxy monoterpenoid (up to 46.9 %) in the oil. Three minor isomers: cis is...
متن کاملAntifungal Properties of Chenopodium ambrosioides Essential Oil Against Candida Species
The essential oil of the aerial part (leaves, flowers and stem) of Chenopodium ambrosioides was obtained by hydrodistillation and its chemical composition analyzed by GC and GC/MS, which permitted the identification of 14 components, representing 98.8% of the total oil. Major components were α-terpinene (51.3%), p-cymene (23.4%) and p-mentha-1,8-diène (15.3%). The antifungal properties of this ...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2010
ISSN: 1471-2210
DOI: 10.1186/1471-2210-10-s1-a10